![]() ![]() Gastrointestinal Bleeding, Ulceration, and Perforation VOLTAREN GEL is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.This risk may occur early in treatment and may increase with duration of use. Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. ![]() WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS Digoxin: Concomitant use with VOLTAREN GEL can increase serum concentration and prolong half-life of digoxin.Monitor patients to assure diuretic efficacy including antihypertensive effects ( 7) Diuretics: NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.In such high risk patients, monitor for signs of worsening renal function ( 7) ACE Inhibitors and ARBs: Concomitant use with VOLTAREN GEL in elderly, volume depleted, or those with renal impairment may result in deterioration of renal function.ACE Inhibitors, Angiotensin Receptor Blockers (ARB), or Beta-Blockers: Concomitant use with VOLTAREN GEL may diminish the antihypertensive effect of these drugs.Concomitant use of VOLTAREN GEL and analgesic doses of aspirin is not generally recommended ( 7) warfarin, aspirin, SSRIs/SNRIs): Monitor patients for bleeding who are concomitantly using VOLTAREN GEL with drugs that interfere with hemostasis. Drugs that Interfere with Hemostasis (e.g.Hematologic Toxicity: Monitor hemoglobin or hematocrit in patients with any signs or symptoms of anemia ( 5.11, 7).Premature Closure of Fetal Ductus Arteriosus: Avoid use in pregnant women starting at 30 weeks gestation.Serious Skin Reactions: Discontinue VOLTAREN GEL at first appearance of rash or other signs of hypersensitivity ( 5.9).Monitor patients with preexisting asthma (without aspirin sensitivity) ( 5.8) Exacerbation of Asthma Related to Aspirin Sensitivity: VOLTAREN GEL is contraindicated in patients with aspirin-sensitive asthma.Anaphylactic Reactions: Seek emergency help if an anaphylactic reaction occurs ( 5.7).Avoid use of VOLTAREN GEL in patients with advanced renal disease unless benefits are expected to outweigh risk of worsening renal function ( 5.6) Renal Toxicity: Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia.Heart Failure and Edema: Avoid use of VOLTAREN GEL in patients with severe heart failure unless benefits are expected to outweigh risk of worsening heart failure ( 5.5).Hypertension: Patients taking some antihypertensive medications may have impaired response to these therapies when taking NSAIDs.Discontinue if abnormal liver tests persist or worsen or if clinical signs and symptoms of liver disease develop ( 5.3) Hepatotoxicity: Inform patients of warning signs and symptoms of hepatotoxicity. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |